Frequently Asked Questions

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How do I know if I have IBS-D?

A: If you experience diarrhea and abdominal pain on a regular basis, you may have IBS-D. Only a qualified healthcare professional can diagnose IBS-D, so discuss your symptoms with your doctor. 

What is Xifaxan?

A: Xifaxan is a prescription antibiotic that works mainly in the digestive tract. Xifaxan tablets are indicated for the treatment of irritable bowel syndrome with diarrhea (IBS-D) in adults. 

What kind of relief does Xifaxan provide?

A: Xifaxan can provide relief from your IBS-D symptoms for 6 to 24 weeks, with an average of 10 weeks. 

What should I do if I miss a dose?

A: Although you may feel better early in the course of treatment, Xifaxan should be taken exactly as directed. Skipping doses or not completing the full course of therapy may (1) decrease the effectiveness of the immediate treatment, and (2) increase the likelihood that bacteria will develop resistance and will not be treatable by Xifaxan or other antibacterial drugs in the future.

If my symptoms come back, can I take Xifaxan again?

A: People whose symptoms return after a period of relief may be treated with Xifaxan again up to 2 times. If your symptoms return, they may not be as severe as they were previously. But if they’re bothering you again, ask your doctor whether another treatment with Xifaxan may help provide relief. 

Does Xifaxan have any side effects?

A: The most common side effects for Xifaxan in IBS-D were nausea (feeling sick to your stomach) and an increase in liver enzymes. These are not all the possible side effects of Xifaxan. Call your doctor for medical advice about side effects.

You are encouraged to report negative side effects of prescription drugs to the FDA.
Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

 

Can I take Xifaxan with other drugs?

A: Tell your doctor if you are taking drugs called P-glycoprotein inhibitors (such as cyclosporine) because using these drugs while you’re taking Xifaxan may lead to an increase in the amount of Xifaxan absorbed by your body. 

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INDICATIONS

XIFAXAN® (rifaximin) 550 mg tablets are indicated for the treatment of irritable bowel syndrome with diarrhea (IBS-D) in adults and for the reduction in risk of overt hepatic encephalopathy (HE) recurrence in adults.

IMPORTANT SAFETY INFORMATION
  • XIFAXAN is not for everyone. Do not take XIFAXAN if you have a known hypersensitivity to rifaximin, any of the rifamycin antimicrobial agents, or any of the components in XIFAXAN
  • If you take antibiotics, like XIFAXAN, there is a chance you could experience diarrhea caused by an overgrowth of bacteria (C. difficile). This can cause symptoms ranging in severity from mild diarrhea to life-threatening colitis. Contact your healthcare provider if your diarrhea does not improve or worsens.
  • Talk to your healthcare provider before taking XIFAXAN if you have severe hepatic (liver) impairment as this may cause increased effects of the medicine.
  • Tell your healthcare provider if you are taking drugs called P-glycoprotein inhibitors (such as cyclosporine) because using these drugs with XIFAXAN may lead to an increase in the amount of XIFAXAN absorbed by your body.
  • If you are pregnant, planning to become pregnant, or nursing, talk to your healthcare provider before taking XIFAXAN because XIFAXAN may cause harm to an unborn baby or nursing infant.
  • In clinical studies, the most common side effects of XIFAXAN were:
    • HE: peripheral edema (swelling, usually in the ankles or lower limbs), nausea (feeling sick to your stomach), dizziness, fatigue (feeling tired), and ascites (a buildup of fluid in the abdomen).
    • IBS-D: Nausea (feeling sick to your stomach) and an increase in liver enzymes.

Please click here for full Prescribing Information for XIFAXAN.

The health information contained herein is provided for educational purposes only and is not intended to replace discussions with a healthcare provider. All decisions regarding patient care must be made with a healthcare provider, considering the unique characteristics of the patient.

The product information provided in this site is intended only for residents of the United States. The products discussed herein may have different product labeling in different countries.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.
For product information, adverse event reports, and product complaint reports, please contact:
Salix Product Information Call Center
Phone: 1-800-321-4576
Fax: 1-510-595-8183
Email: salixmc@dlss.com

Use of this site signifies your agreement to the Legal Notice and Privacy Policy.
Salix Pharmaceuticals
400 Somerset Corporate Boulevard | Bridgewater, NJ 08807  

The Xifaxan 550 mg product and the Xifaxan trademark are licensed by Alfa Wassermann S.p.A. to Salix Pharmaceuticals or its affiliates. The Gut Guy character is a copyright and trademark of Salix Pharmaceuticals or its affiliates.

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INDICATIONS

XIFAXAN® (rifaximin) 550 mg tablets are indicated for the treatment of irritable bowel syndrome with diarrhea (IBS-D) in adults and for the reduction in risk of overt hepatic encephalopathy (HE) recurrence in adults.

IMPORTANT SAFETY INFORMATION
  • XIFAXAN is not for everyone. Do not take XIFAXAN if you have a known hypersensitivity to rifaximin, any of the rifamycin antimicrobial agents, or any of the components in XIFAXAN
  • If you take antibiotics, like XIFAXAN, there is a chance you could experience diarrhea caused by an overgrowth of bacteria (C. difficile). This can cause symptoms ranging in severity from mild diarrhea to life-threatening colitis. Contact your healthcare provider if your diarrhea does not improve or worsens.
  • Talk to your healthcare provider before taking XIFAXAN if you have severe hepatic (liver) impairment as this may cause increased effects of the medicine.
  • Tell your healthcare provider if you are taking drugs called P-glycoprotein inhibitors (such as cyclosporine) because using these drugs with XIFAXAN may lead to an increase in the amount of XIFAXAN absorbed by your body.
  • If you are pregnant, planning to become pregnant, or nursing, talk to your healthcare provider before taking XIFAXAN because XIFAXAN may cause harm to an unborn baby or nursing infant.
  • In clinical studies, the most common side effects of XIFAXAN were:
    • HE: peripheral edema (swelling, usually in the ankles or lower limbs), nausea (feeling sick to your stomach), dizziness, fatigue (feeling tired), and ascites (a buildup of fluid in the abdomen).
    • IBS-D: Nausea (feeling sick to your stomach) and an increase in liver enzymes.

Please click here for full Prescribing Information for XIFAXAN.

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