What is XIFAXAN (zī-fax-an)?

XIFAXAN is a nonsystemic* antibiotic that slows the growth of bacteria in the gut that are believed to be linked to symptoms of overt hepatic encephalopathy (HE). It has been proven to reduce the risk of overt HE recurrence and HE-related hospitalizations in adults.

*There is an increased systemic exposure in patients with severe (Child-Pugh Class C) hepatic impairment. Caution should be exercised when administering XIFAXAN to these patients.

XIFAXAN reduced two risks associated with overt HE

In a clinical study, adults with a history of overt HE took one XIFAXAN 550 mg tablet 2 times a day for 6 months. 91% of patients took lactulose at the same time. The results were:

Graphic that reads 'Reduced risks of another overt HE episode by 58% (compared to placebo)' Graphic that reads 'Reduced risk of another HE-related hospitalization by 50% (compared to placebo)'
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Common side effects of XIFAXAN

In the same clinical study, the most common side effects reported by patients (occurring in at least 5% of them and at a higher rate than in patients taking placebo) were:

  • Peripheral edema (swelling, usually in the ankles or lower legs)
  • Nausea (feeling sick to one’s stomach)
  • Dizziness
  • Fatigue (feeling tired)
  • Ascites (a buildup of fluid in the abdomen)

These are not all of the side effects of XIFAXAN. Please see additional Important Safety Information below and click here for full Prescribing Information.

How to take XIFAXAN

  • XIFAXAN for HE comes as a 550 mg tablet that is taken 2 times a day, as recommended by a healthcare provider.
  • XIFAXAN can be taken with or without food.
  • XIFAXAN should be taken as long as a healthcare provider recommends.
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