What is XIFAXAN (zī-fax-an)?

XIFAXAN is a nonsystemic* antibiotic that slows the growth of bacteria in the gut that are believed to be linked to symptoms of overt hepatic encephalopathy (HE).

*Talk to your healthcare provider before taking XIFAXAN if you have severe hepatic (liver) impairment, as this may cause increased effects of the medicine.

XIFAXAN reduced two risks associated with overt HE

In a clinical study, adults with a history of overt HE took one XIFAXAN 550 mg tablet 2 times a day for 6 months. 91% of patients took lactulose at the same time. The results were:

Graphic that reads reduced risks of another overt he episode by 58% (compared to placebo)

XIFAXAN group: 22% of patients reported breakthrough HE episodes

Placebo group: 46% of patients reported breakthrough HE episodes

Graphic that reads reduced risk of another he-related hospitalization by 50% (compared to placebo)

XIFAXAN group: 14% of patients had a hospitalization involving HE

Placebo group: 23% of patients had a hospitalization involving HE

Photograph of a woman

Common side effects of XIFAXAN

In the same clinical study, the most common side effects reported by patients taking XIFAXAN (occurring in at least 10% of them and at a higher rate than in patients taking placebo) were:

  • Peripheral edema (swelling, usually in the ankles or lower legs)
  • Nausea (feeling sick to one’s stomach)
  • Dizziness
  • Fatigue (feeling tired)
  • Ascites (a buildup of fluid in the abdomen)

These are not all of the side effects of XIFAXAN. Please see additional Important Safety Information below and click here for full Prescribing Information.

How to take XIFAXAN

  • XIFAXAN for OHE comes as a 550 mg tablet that is taken 2 times a day, as recommended by a healthcare provider.
  • XIFAXAN can be taken with or without food.
  • XIFAXAN should be taken as long as a healthcare provider recommends.
Photograph of Xifaxan bottle
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