Yes, the most common side effects reported by patients taking XIFAXAN (occurring in at least 10% of them and at a higher rate than in patients taking placebo) were:
- Peripheral edema (swelling, usually in the ankles or lower legs)
- Nausea (feeling sick to one’s stomach)
- Fatigue (feeling tired)
- Ascites (a buildup of fluid in the abdomen)
XIFAXAN is not for everyone. Do not take XIFAXAN if you have a known hypersensitivity to rifaximin, any of the rifamycin antimicrobial agents, or any of the components in XIFAXAN.
If you take antibiotics, like XIFAXAN, there is a chance you could experience diarrhea caused by an overgrowth of bacteria (C. difficile). This can cause symptoms ranging in severity from mild diarrhea to life-threatening colitis. Contact your healthcare provider if your diarrhea does not improve or worsens.
These are not all of the possible side effects of XIFAXAN. Call your doctor for medical advice about XIFAXAN side effects.
You are encouraged to report negative side effects of prescription drugs to the FDA.
Visit , or call 1-800-FDA-1088.
Please see additional important safety information below.