If you experience diarrhea and abdominal pain on a regular basis, you may have IBS-D. Only a qualified healthcare professional can diagnose IBS-D, so discuss your symptoms with your doctor.

XIFAXAN is a prescription antibiotic that works mainly in the digestive tract. XIFAXAN 550 mg tablets are indicated for the treatment of irritable bowel syndrome with diarrhea (IBS-D) in adults. It is a 2-week treatment. In a clinical trial, patients experienced up to 6 months of symptom relief from abdominal pain and diarrhea.^‡ You can be retreated up to 2 times if symptoms come back. Talk to your healthcare provider before taking XIFAXAN if you have severe hepatic (liver) impairment, as this may cause increased effects of the medicine.

XIFAXAN can provide lasting and significant relief of abdominal pain and diarrhea for up to 6 months.^‡ If you’ve been living with IBS-D symptoms, it may be time to talk with your doctor about XIFAXAN.

Although you may feel better early in the course of treatment, XIFAXAN should be taken exactly as directed. Skipping doses or not completing the full course of therapy may (1) decrease the effectiveness of the immediate treatment, and (2) increase the likelihood that bacteria will develop resistance and will not be treatable by XIFAXAN or other antibacterial drugs in the future.

If your symptoms return after a period of relief, you may find that they are not as severe as they were previously. But if your symptoms are bothering you, ask your doctor if another treatment with XIFAXAN may help provide IBS-D relief. You can be retreated up to two times if symptoms return.

The most common side effect for XIFAXAN in IBS-D was nausea (feeling sick to your stomach), experienced by 3% of people in two clinical trials. In a third clinical trial, 2% of the people taking XIFAXAN experienced nausea and 2% showed an increase in liver enzymes.

If you take antibiotics, like XIFAXAN, there is a chance you could experience diarrhea caused by an overgrowth of bacteria (C. difficile). This can cause symptoms ranging in severity from mild diarrhea to life-threatening colitis. Contact your healthcare provider if your diarrhea does not improve or worsens.

XIFAXAN is not for everyone. Do not take XIFAXAN if you have a known hypersensitivity to rifaximin, any of the rifamycin antimicrobial agents, or any of the components in XIFAXAN.

These are not all of the possible side effects of XIFAXAN. Call your doctor for medical advice about XIFAXAN side effects.

Please click here for full Prescribing Information for XIFAXAN.

You are encouraged to report negative side effects of prescription drugs to the FDA.
Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

Tell your doctor if you are taking drugs called P-glycoprotein inhibitors (such as cyclosporine), because using these drugs while taking XIFAXAN may lead to an increase in the amount of XIFAXAN absorbed by your body.

XIFAXAN may affect warfarin activity when taken together. Tell your doctor if you are taking warfarin because the dose of warfarin may need to be adjusted to maintain proper blood-thinning effect.

Tell your doctor about all of the medicines you take including prescription medicines, over-the counter medicines, supplements or herbal medicines.