XIFAXAN is the only FDA-approved medicine for the reduction in risk of overt HE (hepatic encephalopathy) recurrence in adults

Talk to your doctor about how you can help reduce the risk of another overt HE episode with XIFAXAN or connect with a Nurse Navigator* for additional resources.

*Patient is not eligible to use our Navigator services if he/she participates in or seeks reimbursement, or submits a claim for reimbursement to any federal or state healthcare program with prescription drug coverage.

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FAQs

The symptoms of HE can be mental and physical and can vary in degree:

  • “Covert” HE symptoms can go unnoticed, even by a doctor
  • “Overt” HE symptoms are more noticeable to other people

Symptoms of overt HE can include:

Mental

  • Lack of energy or interest
  • Confusion
  • Not knowing where you are or where you’re going
  • Inappropriate behavior
  • Severe personality change

Physical

  • Sleepiness or change in sleep patterns
  • Worsening of handwriting
  • Loss of small hand movements
  • Tremors or shaking of hands or arms
  • Breath with a musty or sweet odor

These symptoms may also be found in older people with Alzheimer’s or dementia, but when they occur in people with liver disease, it may be HE.

If you have some form of liver disease and you start to develop any of these symptoms, it is important that you talk about them with your doctor.

When HE symptoms become more severe, the condition is called “overt HE.” If you have overt HE, you may have experienced what is called an “episode” of overt HE.

During an episode, your symptoms can become more obvious. There may be a change in your behavior or personality. You may not understand what is happening, and people around you may notice that you are acting strangely.

Many episodes of overt HE end at the hospital, where you may be taken by a friend or loved one for medical attention.

If you have experienced an episode of overt HE, you also have a higher risk of having another overt HE episode in the future. But there are ways to help reduce the risk of additional overt HE episodes.

XIFAXAN was studied to see how it impacted adults with overt HE. In this study of 299 adults with a recent history of overt HE, those who took XIFAXAN had a lower risk of having another overt HE episode compared to those who did not take XIFAXAN. People taking XIFAXAN also had a lower risk of having an HE-related hospitalization compared to those who did not take XIFAXAN. 91% of patients in the study were also on lactulose at the same time.

Click here to look at the data.

The most common side effects reported by patients taking XIFAXAN (occurring in at least 10% of them and at a higher rate than in patients taking placebo) were:

  • Peripheral edema (swelling, usually in the ankles or lower legs)
  • Nausea (feeling sick to one’s stomach)
  • Dizziness
  • Fatigue (feeling tired)
  • Ascites (a buildup of fluid in the abdomen)

Please see additional Important Safety Information below and click here for full Prescribing Information.

If you are prescribed XIFAXAN, the recommended dose is 1 tablet of XIFAXAN by mouth 2 times a day (1 in the morning and 1 at night) to help reduce the risk of additional overt HE episodes. You can take XIFAXAN with or without food.

You should keep taking XIFAXAN for as long as your doctor recommends. Continuing to take your medicine is an important part of any plan to manage overt HE.

Copay card

Save on your XIFAXAN prescription

The XIFAXAN Instant Copay Savings Card provides most eligible commercially insured patients help with their monthly copays for XIFAXAN.

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Patient is not eligible if he/she participates in or seeks reimbursement or submits a claim for reimbursement to any federal or state healthcare program with prescription drug coverage, such as Medicaid, Medicare, Medigap, VA, DOD, TRICARE, or any similar federal or state healthcare program (each a Government Program), or where prohibited by law. Patient must be enrolled in, and must seek reimbursement from or submit a claim for reimbursement to, a commercial insurance plan. Offer excludes full cash-paying patients. Maximum benefits and other restrictions apply. Visit https://xifaxan.copaysavingsprogram.com/ or call 1-866-XIFAXAN for full eligibility criteria, terms and conditions.

HE, hepatic encephalopathy; OHE, overt hepatic encephalopathy.

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INDICATIONS

XIFAXAN® (rifaximin) 550 mg tablets are indicated for the reduction in risk of overt hepatic encephalopathy (HE) recurrence in adults and for the treatment of irritable bowel syndrome with diarrhea (IBS-D) in adults.

XIFAXAN® (rifaximin) 550 mg tablets are indicated for the reduction in risk of overt hepatic encephalopathy (HE) recurrence in adults.

IMPORTANT SAFETY INFORMATION

  • XIFAXAN is not for everyone. Do not take XIFAXAN if you have a known hypersensitivity to rifaximin, any of the rifamycin antimicrobial agents, or any of the components in XIFAXAN.
  • If you take antibiotics, like XIFAXAN, there is a chance you could experience diarrhea caused by an overgrowth of bacteria (C. difficile). This can cause symptoms ranging in severity from mild diarrhea to life-threatening colitis. Contact your healthcare provider if your diarrhea does not improve or worsens.
  • XIFAXAN is not for everyone. Do not take XIFAXAN if you have a known hypersensitivity to rifaximin, any of the rifamycin antimicrobial agents, or any of the components in XIFAXAN.
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INDICATIONS

XIFAXAN® (rifaximin) 550 mg tablets are indicated for the reduction in risk of overt hepatic encephalopathy (HE) recurrence in adults and for the treatment of irritable bowel syndrome with diarrhea (IBS-D) in adults.

IMPORTANT SAFETY INFORMATION

  • XIFAXAN is not for everyone. Do not take XIFAXAN if you have a known hypersensitivity to rifaximin, any of the rifamycin antimicrobial agents, or any of the components in XIFAXAN.
  • If you take antibiotics, like XIFAXAN, there is a chance you could experience diarrhea caused by an overgrowth of bacteria (C. difficile). This can cause symptoms ranging in severity from mild diarrhea to life-threatening colitis. Contact your healthcare provider if your diarrhea does not improve or worsens.
  • Talk to your healthcare provider before taking XIFAXAN if you have severe hepatic (liver) impairment, as this may cause increased effects of the medicine.
  • Tell your healthcare provider if you are taking drugs called P-glycoprotein and/or OATPs inhibitors (such as cyclosporine) because using these drugs with XIFAXAN may lead to an increase in the amount of XIFAXAN absorbed by your body.
  • In clinical studies, the most common side effects for XIFAXAN were:
    • - HE: Peripheral edema (swelling, usually in the ankles or lower limbs), constipation, nausea (feeling sick to your stomach), fatigue (feeling tired), insomnia (trouble sleeping), ascites (a buildup of fluid in the abdomen), dizziness, urinary tract infection, anemia (low red blood cell levels), and itching
    • - IBS-D: Nausea (feeling sick to your stomach) and an increase in liver enzymes
  • XIFAXAN may affect warfarin activity when taken together. Tell your healthcare provider if you are taking warfarin because the dose of warfarin may need to be adjusted to maintain proper blood-thinning effect.
  • If you are pregnant, planning to become pregnant, or nursing, talk to your healthcare provider before taking XIFAXAN because XIFAXAN may cause harm to an unborn baby or nursing infant.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch/ or call 1-800-FDA-1088.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch/ or call 1-800-FDA-1088.

For product information, adverse event reports, and product complaint reports, please contact:

Salix Product Information Call Center
Phone: 1-800-321-4576
Fax: 1-510-595-8183
Salix Product Information Call Center
Phone: 1-800-321-4576
Fax: 1-510-595-8183

Please click here for full Prescribing Information.

XIF.0209.USA.23