XIFAXAN is a prescription medicine that helps you break free from IBS-D symptoms of abdominal pain and diarrhea, providing significant relief that lasts.*
XIFAXAN is the only FDA-approved 2-week treatment for IBS-D.

IBS-D = irritable bowel syndrome with diarrhea.

*In a clinical trial: range of 6 to 24 weeks; average of 10 weeks.

†You can be retreated up to two times if symptoms come back.


XIFAXAN is a short-course treatment, not something you take indefinitely.

XIFAXAN is different from other IBS-D treatments. You take it every day for 2 weeks for up to 6 months*† of relief from IBS-D symptoms.

In clinical trials, patients reported that recurring symptoms were less severe than when they first started on XIFAXAN. Patients who experienced recurring symptoms were retreated with XIFAXAN up to 2 times.

*In a clinical trial: range of 6 to 24 weeks; average of 10 weeks.
You can be retreated up to two times if symptoms come back.

The Gut Guy character


The exact cause of IBS-D is unknown. However, it is believed that an imbalance of gut bacteria may lead to IBS-D symptoms.

XIFAXAN is the only FDA-approved treatment that alters the bacteria in your gut that have been linked to symptoms of IBS-D.

XIFAXAN is an antibacterial medication, or antibiotic, that did not cause any clinically relevant antibiotic resistance after 1 to 3 treatment cycles.

If you take antibiotics, like XIFAXAN, there is a chance you could experience diarrhea caused by an overgrowth of bacteria (C. difficile). This can cause symptoms ranging in severity from mild diarrhea to life-threatening colitis. Contact your healthcare provider if your diarrhea does not improve or worsens.

Most common side effects

In clinical studies, the most common side effects associated with XIFAXAN for IBS-D were:

• Nausea (feeling sick to your stomach)
• An increase in liver enzymes

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XIFAXAN is a tablet that you take 3 times a day for 2 weeks

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Always take XIFAXAN 550 mg tablets exactly as your doctor tells you

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XIFAXAN tablets can be taken with or without food

$0 copay available for eligible commercially insured patients with coverage for Xifaxan


"Get Instant Co-Pay Savings"

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