Understanding IBS-D

Get the facts about IBS-D

Irritable bowel syndrome with diarrhea (IBS-D) is a common disorder of the large intestine (colon). Many others like you struggle with IBS-D.

Finding the right treatment for IBS-D can be a long and difficult process to navigate. Talk to your doctor to see if XIFAXAN is right for you.

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Causes of IBS-D

Bacteria

Causes of IBS-D

IBS-D is a complicated condition with several factors that can affect the digestive system; however, the precise cause of IBS-D is unknown.

An imbalance in the normal healthy bacteria in the digestive system has been found in some people with IBS-D. The bacteria and microorganisms in your digestive system, collectively called the microbiota, help you digest and absorb food and are constantly working to keep your body functioning normally.*

*Other factors could include improper signaling between the brain and the digestive system, inflammation or severe infection in the intestines, too strong or weak intestinal muscle contractions, family history and genetics, and—in some cases—anxiety and/or depression.

Common IBS-D symptoms

IBS-D patients often suffer from multiple symptoms that can vary over time. Some of the most common symptoms of IBS-D can be difficult to manage.

Abdominal pain

Abdominal pain

Frequent stomach discomfort resulting in distraction from what matters

Diarrhea icon

Diarrhea

Loose, mushy, or watery stools and/or frequent bowel movements

Bloating

Bloating

Abdominal discomfort due to excessive intestinal gasses

Urgency

Urgency

The unpleasant sensation to rush to the toilet to have a bowel movement

Talk to your doctor about symptoms and experiences so they can determine if you have IBS-D and find a treatment that’s right for you.

How is IBS-D diagnosed?

Doctors can now diagnose IBS-D based on your symptom history, which means medical tests aren’t typically needed. Your doctor may ask:

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Has your stomach pain been bothering you for an average of at least 1 day every week for the last 3 months?

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Are more than 25% of your stools/bowel movements loose or watery (diarrhea) and are less than 25% hard or lumpy (constipation)?

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Did your symptoms start at least 6 months ago?

Connect with a Nurse Navigator to learn more about XIFAXAN or receive additional resources.

Download our discussion guide for when you talk to your doctor.

There’s no one profile for a person who will develop IBS, but

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AS MANY WOMEN AS MEN SUFFER FROM IBS

IBS MORE OFTEN OCCURS IN PEOPLE YOUNGER THAN

45

Living with IBS-D

Everyday life and commitments can be a challenge if you are suffering from IBS-D.

The unpredictability of symptoms may cause you to

  • Limit your social life
  • Stay home from work or school
  • Avoid traveling long distances
  • Avoid favorite foods or drinks
  • Constantly plan for the bathroom
Living with IBSD

Tips for managing your IBS-D

Depending on what triggers your symptoms, there are some lifestyle changes that could help.

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Tips for managing your IBS-D

Depending on what triggers your symptoms, there are some lifestyle changes that could help.

  • People living with IBS-D have had success reducing symptoms with regular exercise, meditation, and other stress-reducing techniques
  • Eliminating trigger foods from your diet, such as those that cause gas or contain gluten, can make a difference
  • Stay educated about IBS-D
    and talk to your doctors
  • Join local or online support groups for advocacy, support, and information from others about lifestyle changes that may help

IBS-D treatments

If your lifestyle changes or your medication hasn’t helped, ask your doctor about XIFAXAN. There are different types of prescription treatments for IBS-D, so if one isn’t working, talk to your doctor about your symptoms to help decide which treatment option is right for you.

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INDICATIONS

XIFAXAN® (rifaximin) 550 mg tablets are indicated for the reduction in risk of overt hepatic encephalopathy (HE) recurrence in adults and for the treatment of irritable bowel syndrome with diarrhea (IBS-D) in adults.

XIFAXAN® (rifaximin) 550 mg tablets are indicated for the treatment of irritable bowel syndrome with diarrhea (IBS-D) in adults.

IMPORTANT SAFETY INFORMATION

  • XIFAXAN is not for everyone. Do not take XIFAXAN if you have a known hypersensitivity to rifaximin, any of the rifamycin antimicrobial agents, or any of the components in XIFAXAN.
  • If you take antibiotics, like XIFAXAN, there is a chance you could experience diarrhea caused by an overgrowth of bacteria (C. difficile). This can cause symptoms ranging in severity from mild diarrhea to life-threatening colitis. Contact your healthcare provider if your diarrhea does not improve or worsens.
  • XIFAXAN is not for everyone. Do not take XIFAXAN if you have a known hypersensitivity to rifaximin, any of the rifamycin antimicrobial agents, or any of the components in XIFAXAN.
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INDICATIONS

XIFAXAN® (rifaximin) 550 mg tablets are indicated for the reduction in risk of overt hepatic encephalopathy (HE) recurrence in adults and for the treatment of irritable bowel syndrome with diarrhea (IBS-D) in adults.

XIFAXAN® (rifaximin) 550 mg tablets are indicated for the treatment of irritable bowel syndrome with diarrhea (IBS-D) in adults.

IMPORTANT SAFETY INFORMATION

  • XIFAXAN is not for everyone. Do not take XIFAXAN if you have a known hypersensitivity to rifaximin, any of the rifamycin antimicrobial agents, or any of the components in XIFAXAN.
  • If you take antibiotics, like XIFAXAN, there is a chance you could experience diarrhea caused by an overgrowth of bacteria (C. difficile). This can cause symptoms ranging in severity from mild diarrhea to life-threatening colitis. Contact your healthcare provider if your diarrhea does not improve or worsens.
  • Talk to your healthcare provider before taking XIFAXAN if you have severe hepatic (liver) impairment, as this may cause increased effects of the medicine.
  • Tell your healthcare provider if you are taking drugs called P-glycoprotein and/or OATPs inhibitors (such as cyclosporine) because using these drugs with XIFAXAN may lead to an increase in the amount of XIFAXAN absorbed by your body.
  • In clinical studies, the most common side effects for XIFAXAN were:
    • - HE: Peripheral edema (swelling, usually in the ankles or lower limbs), constipation, nausea (feeling sick to your stomach), fatigue (feeling tired), insomnia (trouble sleeping), ascites (a buildup of fluid in the abdomen), dizziness, urinary tract infection, anemia (low red blood cell levels), and itching
    • - IBS-D: Nausea (feeling sick to your stomach) and an increase in liver enzymes
  • XIFAXAN may affect warfarin activity when taken together. Tell your healthcare provider if you are taking warfarin because the dose of warfarin may need to be adjusted to maintain proper blood-thinning effect.
  • If you are pregnant, planning to become pregnant, or nursing, talk to your healthcare provider before taking XIFAXAN because XIFAXAN may cause harm to an unborn baby or nursing infant.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch/ or call 1-800-FDA-1088.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch/ or call 1-800-FDA-1088.

For product information, adverse event reports, and product complaint reports, please contact:

Salix Product Information Call Center
Phone: 1-800-321-4576
Fax: 1-510-595-8183
Salix Product Information Call Center
Phone: 1-800-321-4576
Fax: 1-510-595-8183

Please click here for full Prescribing Information. RX only.

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